The Jordan Lab

Our research focuses on understanding the molecular mechanisms regulating DNA repair, chromosome segregation and cell cycle progression. Our lab studies the importance of Structural Maintenance of Chromosomes (SMC) complexes and cell cycle kinases, particularly Polo-like (PLK) kinases and Aurora kinases. We use mouse as a model organism to study consequences of gene mutation and chromosome missegregation, which give rise to physical and cognitive developmental defects, infertility and cancer predisposition. We also use mouse and human pluripotent stem cells to help define the function of these proteins within essential molecular pathways of the cell. Our current research encompasses the following:

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1) Gametogenesis (spermatogenesis and oogenesis)

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2) Pluripotent stem cell genome maintenance

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3) Neurodevelopment