Creation of new embryonic stem cell and mouse models
Our lab is creating new embryonic stem cell (ESC) and mutant mouse models.
Using CRISPR/Cas9 gene targeting technology we are developing ESC lines that harbor an Auxin Inducible Degron (AID) system. The AID system allows us to specifically target a protein of interest for proteosomal degradation. This system is highly advantageous as it is rapid, reversible, titratable,
We are using Cas9 to combining