My research focuses on utilizing transgenic mice to study the regulation of chromosome segregation and genome maintenance in germ cell progression. Using a combination of genetic and cellular approaches, I investigate the functions of structural maintenance of chromosome (SMC) complexes in the mammalian model system.
The structural maintenance of chromosomes (SMC) complex family, which includes cohesin, condensin, and SMC5/6, are essential for chromosome organization and dynamics during various important cellular processes. The complexes are vital for replication, chromosome condensation, sister-chromatid cohesion, recombination, and DNA repair. While functions of cohesin and condensin have been explored, the functions of the SMC5/6 complex during mammalian gametogenesis have yet to be discovered. By characterizing conditional mutant mice, my project focuses on determining how SMC5/6 complex regulates genome maintenance during gametogenesis to early embryogenesis in both sexes.
Past Research Experience:
Generation of genetic mosaic screens for studying Drosophila ovarian stem cells
Analysis of systemic signals affecting Drosophila ovarian stem cell proliferation and maintenance
Characterization and analysis of genetic mutants in Drosophila using confocal microscopy
See my LinkedIn and profile for more info.